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58-20-8 Cypionate Testosterone Anabolic Steroid Andronate Deposteron

Categories Testosterone Anabolic Steroid
Brand Name: KANGDISEN
Model Number: white powder
Certification: GMP
Place of Origin: China
MOQ: negotiatable
Price: negotiatable
Payment Terms: MoneyGram, T/T. Bitcoin
Supply Ability: 5000 tons each month
Delivery Time: 3 days
Packaging Details: sealed
CAS: 58-20-8
Molar mass: 412.6047 g/mol
PubChem (CID): 441404
Formula: C27H40O3
ChEMBL: CHEMBL1201101
Synonyms: Andro Cyp, Andronaq LA, Andronate, Dep Andro, Dep Test, Deposteron, Depostomead, Depotest, Depo-Testosterone, Depovirin, Durandro, Duratest, Jectatest, Malogen CYP, Pertestis, Testa-C, Testadiate Depo, Testex Elmu Prolongatum, Testoject LA, Virilon
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    58-20-8 Cypionate Testosterone Anabolic Steroid Andronate Deposteron

    58-20-8 Cypionate Testosterone Anabolic Steroid Andronate Deposteron


    We can supply its raw material powder with the best quality and price.


    Testosterone cypionate (brand names Depo-Testosterone, many others), or testosterone cipionate, also known as testosterone cyclopentylpropionate or testosterone cyclopentanepropionate, is an androgen and anabolic steroid and a testosterone ester. Along with testosterone enanthate, testosterone propionate, and testosterone undecanoate, it is one of the most widely used testosterone esters.


    Testosterone Cypionate Description


    Testosterone Cypionate Injection, for intramuscular injection, contains Testosterone Cypionate which is the oil-soluble 17 (beta)- cyclopentylpropionate ester of the androgenic hormone testosterone.


    Testosterone Cypionate is a white or creamy white crystalline powder, odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils.


    The chemical name for Testosterone Cypionate is androst-4-en-3-one, 17-(3-cyclopentyl-1-oxopropoxy)-, (17ß)-. Its molecular formula is C27H40O3, and the molecular weight 412.61.


    Testosterone Cypionate Injection is available in two strengths, 100 mg/mL and 200 mg/mL Testosterone Cypionate.


    Each mL of the 100 mg/mL solution contains:
    Testosterone Cypionate100 mg
    Benzyl benzoate0.1 mL
    Cottonseed oil736 mg
    Benzyl alcohol (as preservative)9.45 mg
    Each mL of the 200 mg/mL solution contains:
    Testosterone Cypionate200 mg
    Benzyl benzoate0.2 mL
    Cottonseed oil560 mg
    Benzyl alcohol (as preservative)9.45 mg

    Testosterone is a hormone produced by all human beings and is the primary male sex hormone. Through our discussion, well take a look atTestosterone Cypionate, and examine the pros and cons of its use to improve performance in athletics and bodybuilding. Before we dive in, lets clear up a common misconception. Testosterone Cypionate is no more or less powerful or effective than its counterpart Testosterone Enanthate. The two compounds are virtually identical in every way.


    Testosterone Cypionate Traits


    Testosterone Cypionate is a synthetic version of the naturally produced testosterone hormone. This hormone is responsible for many different physical and mental characteristics in males. It promotes sex drive, fat loss, helps with gaining and maintaining lean muscle mass, increases bone density, and may even protect against heart disease. Whether it is naturally produced or through the use of Testosterone Cypionate, these traits do not change. All other steroids are actually the testosterone molecule that has been altered to change the properties of the hormone.


    Testosterone Cypionate carries a rating of 100 when measuring its anabolic/androgenic structure and this rating is used to measure all other steroids. This would make testosterone the "father" of all anabolic steroids used by athletes today.


    It should be noted; all testosterone compounds, including Testosterone Cypionate carry this anabolic/androgenic score of 100, as they are all merely testosterone.


    Testosterone Cypionate is a highly anabolic and androgenic hormone making it a great steroid to use if one is in pursuit of more size and strength. Testosterone Cypionate promotes nitrogen retention in the muscle and the more nitrogen the muscles hold the more protein the muscles store.


    Testosterone Cypionate can also increase the levels of another anabolic hormone, IGF-1 in muscle tissue providing even more anabolic activity. Testosterone Cypionate also has the amazing ability to increase the activity of satellite cells. These cells play an active role in repairing damaged muscle. Testosterone also binds to the androgen receptor to promote androgen receptor dependent mechanisms for muscle gain and fat loss.


    Testosterone Cypionate induces changes in shape, size and can also change the appearance and the number of muscle fibers. Androgens like testosterone can protect your hard earned muscle from the catabolic (muscle wasting) glucocorticoid hormones, in-turn inhibiting the related adverse reactions. In addition, Testosterone Cypionate has the ability to increase red blood cell production and a higher red blood cell count will improve endurance through increased oxygenation in the blood. More red blood cells can also improve recovery from strenuous physical activity.


    Even so, Testosterones anabolic/androgenic effects are dose dependent; the higher the dose the higher the muscle building effect.


    Many athletes display massive strength gains while using Testosterone Cypionate as the hormone improves muscle contraction by increasing the number of motor neutrons in muscle and improves neuromuscular transmission.


    It also promotes glycogen synthesis providing more fuel for intenseworkouts thereby increasing endurance and strength.


    Testosterone Cypionate also has the ability to promote fat loss through an enhancement of metabolic activity. Testosterone binds to the androgen receptor fairly well resulting in fat breakdown, and further prevents new fat cell formation. Another indirect action of fat loss that testosterone produces is the nutrient portioning effect it has on muscle and fat. Since the body is building muscle at an accelerated rate more of the food you eat is shuttled to muscle tissue instead of being stored as fat; nutrient efficiency is enhanced.


    Testosterone Cypionate will also play a crucial role revolving around creatine. Creatine is essential to adenosine triphosphate (ATP), the source of energy for our muscles and when the muscles are stimulated ATP is broken down into adenosine diphosphate (ADP) and this is what releases energy. Unfortunately, the process is often too slow during strenuous activity but through the use of Testosterone Cypionate, this demand is met as ATP is replenished at a much faster rate.


    Effects of Testosterone Cypionate


    With a well-planned Testosterone Cypionate cycle, nearly every anabolic steroid benefit can be obtained. For the off-season athlete, more lean muscle mass can be built with less body fat gain. In-order to grow, you must consume enough calories and fat gain will occur, but Testosterone Cypionate will ensure the brunt of your weight gain is the weight you want.


    While off-season bulking use is the most common, the effects of Testosterone Cypionate can be tremendously beneficial during the cutting phase too. During this period of use, we are able to preserve far more lean muscle tissue that would otherwise be lost. In-order to lose body fat, we must burn more calories than we consume and this can and often does lead to muscle and strength loss. Further, the longer and harder you diet the more muscle and strength will be at risk, but due to the traits of Testosterone Cypionate muscle tissue and strength are protected.


    Regardless of the purpose of use, Testosterone Cypionate defines performance enhancement by its ability to promote recovery and endurance. With a performance level dose of Testosterone Cypionate your body can recover faster and you wont tire out as quickly. This will allow you toworkout longer and harder, and more progress can be made. This is performance enhancement at its best.


    Testosterone Cypionate Administration


    Testosterone Cypionate is only available in an injectable form and is regularly used to treat conditions such as low testosterone. More than twenty million men in the U.S. alone suffer from some form of low testosterone, and such a condition can severely diminish ones quality of life. Symptoms such as loss of muscle mass and strength, a decrease in libido and sexual performance, an increase in body fat, and low energy levels are all common characteristics of low testosterone.


    Further, when ignored low testosterone can be a gateway to Alzheimers, diabetes, osteoporosis and many other serious conditions. Most men will find one injection every seven to ten days at 100mg to 200mg per injection to completely eradicate such a problem.


    For performance enhancement, one injection per week is often enough; however, in many cases two smaller yet equal sized injections will prove to be far more efficient. The reason for multiple injections is to keep blood levels peaked; further, it is often needed to control side effects that may occur with performance level dosing.


    Like most anabolic steroids, the more you take the greater the reward, but the more you take the greater the risk. By splitting the injections up into smaller more frequent injections, you are introducing smaller amounts of the hormone for your body to deal with all at once. As for the actual performance doses, this can range anywhere from 200mg per week all the way to 1,000mg per week depending on needs and desires.


    The typical dose for those who are using Cypionate to counteract the lowering of testosterone due to the use of other steroids is normally 200mg. If it is being used for direct performance purposes, most will find 400mg to 600mg per week will be effective, but it is important to note that higher doses will greatly increase the risk.


    Regardless of the total dose, most steroid users will find this to be an extremely well-tolerated anabolic steroid and one that can be used for long periods of time. 12 weeks of total use is quite commonplace, as is 16 weeks. There's nothing magical about these numbers, but they are solid guidelines in-order for the individual to plan out his desired goals.


    Regardless of the total dosing or the cycles length, you will need to design a post cycle therapy (PCT) plan once your Testosterone Cypionate use comes to an end. For most men, if you are discontinuing the use of anabolic steroids for more than ten weeks, you will need PCT but if your off period is less then it can be skipped. For full post cycle information and planning, please see the Post Cycle Therapy page on Steroid.com.


    It should be noted; when it comes to performance enhancement, Testosterone Cypionate for women is not recommended. This is a steroid that carries far too much androgenic activity; after all, it is the primary male androgen. Women can suffer from low testosterone and there can be therapeutic benefits from the use of Testosterone Cypionate; however such treatment plans will be tremendously low dosed and should be watched closely for virilization symptoms.


    The Side Effects of Testosterone Cypionate


    As an extremely well-tolerated hormone for most men, the side effects of Testosterone Cypionate are in many ways easy to control. When it comes to such adverse reactions, keep in mind they largely fall into the realm of possible and are by no means guaranteed. Even so, total dosing, genetic predispositions and your overall state of health will play a role.


    As for the side effects themselves, Testosterone Cypionate like all testosterone compounds carries a high level of aromatase activity; aromatization referring to the conversion of testosterone into estrogen. As estrogen levels rise, this can lead to gynecomastia (male breast enlargement) and excess water retention. This excess water retention can even negatively affect blood pressure. In-order to combat such effects, especially gynecomastia, many turn to Selective Estrogen Receptor


    odulators (SERMs) such as Tamoxifen Citrate (Nolvadex) and for more serious protection Aromatase Inhibitors (AIs) such as Anastrozole (Arimidex). Without question, AIs are the most effective; however, they can also prove to be problematic when it comes to cholesterol and caution is advised.


    Beyond these effects, Testosterone Cypionate can promote dihydrotestosterone (DHT) related side effects such as acne, hair loss and prostate enlargement; however, it should go without saying DHT steroids will be the prime culprits. In-order to provide protection, a 5-alpha reductase inhibitor such as Finasteride can be useful as it is an androgen suppressor and the androgen DHT is causing the problem. It must be noted; hair loss is only possible in men predisposed to male pattern baldness.


    Availability of Testosterone Cypionate


    If you live in the U.S. you will not find Testosterone Cypionate for sale on the black market as commonly as you will many other testosterone forms; especially when it comes to pharmaceutical grade. The vast majority of Testosterone Cypionate is manufactured in the U.S. by Upjohn and Watson, and very little ever finds its way to black market suppliers. Of course, outside the U.S. things begin to change as there are quite a few pharmaceutical companies that make it. Further, numerous underground labs across the globe manufacture the product.


    Regardless of the brand you choose, most Testosterone Cypionate comes dosed at 200mg/ml or 250mg/ml. There are a few exceptions; however, most high dosed Testosterone Cypionate normally falls under the category of buyer beware. Such products are commonly under-dosed and are only provided by low-grade underground labs. Of course, regardless of the dosing, you must be very careful when making any anabolic steroid purchase. Contaminated products are not uncommon, and when it comes to human grade Testosterone Cypionate this is one of the most commonly counterfeited testosterones.


    Buying Testosterone Cypionate Online - Warning


    You can easily buy Testosterone Cypionate online; in-fact, this is the easiest and most common way to make an anabolic steroid purchase. Even so, anabolic steroids are classified as Schedule III controlled substances in the U.S. and carry severe legal ramifications if the law is broken. For this reason, if you desire to stay within the safety of the law while meeting your anabolic needs, please see the sponsors and advertisers here at steroid.com. Here you will find high quality anabolics that are not only effective but also legal without a prescription.


    Cypionate Reviews


    With many anabolic steroids to choose from, very few carry such a high level of versatility and toleration as Testosterone Cypionate. Perfect for beginners and long time steroid users in any cycle, it is impossible to go wrong with this steroid.


    If youre new to anabolic steroids and youve maxed out your natural potential, this is the perfect steroid to see your progress continue once again. If you are an advanced steroid user and have used Cypionate in past cycles, it will continue to be just as effective each and every time. This is not an anabolic steroid reserved for a particular group of people, or one that is only useful at one specific time but rather a solid foundational steroid that is perfect for any cycle.


    Testosterone Cypionate - Clinical Pharmacology


    Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body musculature and fat distribution.


    Drugs in this class also cause retention of nitrogen, sodium, potassium, and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.


    Androgens are responsible for the growth spurt of adolescence and for eventual termination of linear growth, brought about by fusion of the epiphyseal growth centers.


    In children, exogenous androgens accelerate linear growth rates, but may cause disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process.


    Androgens have been reported to stimulate production of red blood cells by enhancing production of erythropoietic stimulation factor.

    During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).


    There is a lack of substantial evidence that androgens are effective in fractures, surgery, convalescence, and functional uterine bleeding.


    Pharmacokinetics


    Testosterone esters are less polar than free testosterone. Testosterone esters in oil injected intramuscularly are absorbed slowly from the lipid phase; thus, Testosterone Cypionate can be given at intervals of two to four weeks.


    Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about 2 percent is free. Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life.


    About 90 percent of a dose of testosterone is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of testosterone occurs primarily in the liver. Testosterone is metabolized to various 17-keto steroids through two different pathways.


    The half-life of Testosterone Cypionate when injected intramuscularly is approximately eight days.


    In many tissues the activity of testosterone appears to depend on reduction to dihydrotestosterone, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action.


    Indications and Usage for Testosterone Cypionate


    Testosterone Cypionate Injection is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone.


    1. Primary hypogonadism (congenital or acquired)-testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy.


    2. Hypogonadotropic hypogonadism (congenital or acquired)- gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation.


    Safety and efficacy of Testosterone Cypionate Injection in men with "age-related hypogonadism" (also referred to as "late-onset hypogonadism") have not been established.


    Contraindications


    Known hypersensitivity to the drug

    Males with carcinoma of the breast

    Males with known or suspected carcinoma of the prostate gland

    Women who are or who may become pregnant

    Patients with serious cardiac, hepatic or renal disease


    Warnings


    Hypercalcemia may occur in immobilized patients. If this occurs, the drug should be discontinued.


    Prolonged use of high doses of androgens (principally the 17-α alkyl-androgens) has been associated with development of hepatic adenomas, hepatocellular carcinoma, and peliosis hepatis —all potentially life-threatening complications.


    Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.


    There have been postmarketing reports of venous thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), in patients using testosterone products, such as Testosterone Cypionate. Evaluate patients who report symptoms of pain, edema, warmth and erythema in the lower extremity for DVT and those who present with acute shortness of breath for PE. If a venous thromboembolic event is suspected, discontinue treatment with Testosterone Cypionate and initiate appropriate workup and management.


    Long term clinical safety trials have not been conducted to assess the cardiovascular outcomes of testosterone replacement therapy in men. To date, epidemiologic studies and randomized controlled trials have been inconclusive for determining the risk of major adverse cardiovascular events (MACE), such as non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death, with the use of testosterone compared to non-use.


    Some studies, but not all, have reported an increased risk of MACE in association with use of testosterone replacement therapy in men. Patients should be informed of this possible risk when deciding whether to use or to continue to use Testosterone Cypionate Injection.


    Abuse of Testosterone and Monitoring of Serum Testosterone Concentrations

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. Anabolic androgenic steroid abuse can lead to serious cardiovascular and psychiatric adverse reactions.


    If testosterone abuse is suspected, check serum testosterone concentrations to ensure they are within therapeutic range. However, testosterone levels may be in the normal or subnormal range in men abusing synthetic testosterone derivatives.


    Counsel patients concerning the serious adverse reactions associated with abuse of testosterone and anabolic androgenic steroids. Conversely, consider the possibility of testosterone and anabolic androgenic steroid abuse in suspected patients who present with serious cardiovascular or psychiatric adverse events.


    Edema, with or without congestive heart failure, may be a serious complication in patients with pre-existing cardiac, renal or hepatic disease.


    Gynecomastia may develop and occasionally persists in patients being treated for hypogonadism.


    The preservative benzyl alcohol has been associated with serious adverse events, including the "gasping syndrome", and death in pediatric patients. Although normal therapeutic doses of this product ordinarily deliver amounts of benzyl alcohol that are substantially lower than those reported in association with the "gasping syndrome", the minimum amount of benzyl alcohol at which toxicity may occur is not known.


    The risk of benzyl alcohol toxicity depends on the quantity administered and the liver and kidneys' capacity to detoxify the chemical. Premature and low-birth weight infants may be more likely to develop toxicity.


    Androgen therapy should be used cautiously in healthy males with delayed puberty. The effect on bone maturation should be monitored by assessing bone age of the wrist and hand every 6 months. In children, androgen treatment may accelerate bone maturation without producing compensatory gain in linear growth. This adverse effect may result in compromised adult stature. The younger the child the greater the risk of compromising final mature height.


    This drug has not been shown to be safe and effective for the enhancement of athletic performance. Because of the potential risk of serious adverse health effects, this drug should not be used for such purpose.


    Precautions


    General


    Patients with benign prostatic hypertrophy may develop acute urethral obstruction. Priapism or excessive sexual stimulation may develop. Oligospermia may occur after prolonged administration or excessive dosage. If any of these effects appear, the androgen should be stopped and if restarted, a lower dosage should be utilized.


    Testosterone Cypionate should not be used interchangeably with testosterone propionate because of differences in duration of action.


    Testosterone Cypionate is not for intravenous use.


    Information for patients


    Patients should be instructed to report any of the following: nausea, vomiting, changes in skin color, ankle swelling, too frequent or persistent erections of the penis.


    Laboratory tests


    Hemoglobin and hematocrit levels (to detect polycythemia) should be checked periodically in patients receiving long-term androgen administration.

    Serum cholesterol may increase during androgen therapy.


    Drug interactions


    Androgens may increase sensitivity to oral anticoagulants. Dosage of the anticoagulant may require reduction in order to maintain satisfactory therapeutic hypoprothrombinemia.


    Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.


    In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, insulin requirements.


    Drug/Laboratory test Interferences


    Androgens may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.


    Carcinogenesis


    Animal data


    Testosterone has been tested by subcutaneous injection and implantation in mice and rats. The implant induced cervical-uterine tumors in mice, which metastasized in some cases. There is suggestive evidence that injection of testosterone into some strains of female mice increases their susceptibility to hepatoma. Testosterone is also known to increase the number of tumors and decrease the degree of differentiation of chemically induced carcinomas of the liver in rats.


    Human data


    There are rare reports of hepatocellular carcinoma in patients receiving long-term therapy with androgens in high doses. Withdrawal of the drugs did not lead to regression of the tumors in all cases.

    Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.


    Pregnancy

    Teratogenic Effects

    Pregnancy Category X

    Benzyl alcohol can cross the placenta. .


    Nursing mothers

    Testosterone Cypionate Injection is not recommended for use in nursing mothers.


    Pediatric use


    Safety and effectiveness in pediatric patients below the age of 12 years have not been established.


    Adverse Reactions


    The following adverse reactions in the male have occurred with some androgens:


    Endocrine and urogenital: Gynecomastia and excessive frequency and duration of penile erections. Oligospermia may occur at high dosages.

    Skin and appendages: Hirsutism, male pattern of baldness, seborrhea, and acne.


    Cardiovascular Disorders: myocardial infarction, stroke.

    Fluid and electrolyte disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.


    Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests, rarely hepatocellular neoplasms and peliosis hepatis (see WARNINGS).


    Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.

    Nervous system: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.


    Allergic: Hypersensitivity, including skin manifestations and anaphylactoid reactions.


    Vascular disorders: Venous thromboembolism.


    Miscellaneous: Inflammation and pain at the site of intramuscular injection.

    Drug Abuse and Dependence

    Controlled Substance

    Testosterone Cypionate Injection contains testosterone, a Schedule III controlled substance in the Controlled Substances Act.


    Abuse


    Drug abuse is intentional non-therapeutic use of a drug, even once, for its rewarding psychological and physiological effects. Abuse and misuse of testosterone are seen in male and female adults and adolescents. Testosterone, often in combination with other anabolic androgenic steroids (AAS), and not obtained by prescription through a pharmacy, may be abused by athletes and bodybuilders. There have been reports of misuse by men taking higher doses of legally obtained testosterone than prescribed and continuing testosterone despite adverse events or against medical advice.


    Abuse-Related Adverse Reactions


    Serious adverse reactions have been reported in individuals who abuse anabolic androgenic steroids and include cardiac arrest, myocardial infarction, hypertrophic cardiomyopathy, congestive heart failure, cerebrovascular accident, hepatotoxicity, and serious psychiatric manifestations, including major depression, mania, paranoia, psychosis, delusions, hallucinations, hostility and aggression.


    The following adverse reactions have also been reported in men: transient ischemic attacks, convulsions, hypomania, irritability, dyslipidemias, testicular atrophy, subfertility, and infertility.


    The following additional adverse reactions have been reported in women: hirsutism, virilization, deepening of voice, clitoral enlargement, breast atrophy, male-pattern baldness, and menstrual irregularities.


    The following adverse reactions have been reported in male and female adolescents: premature closure of bony epiphyses with termination of growth, and precocious puberty.


    Because these reactions are reported voluntarily from a population of uncertain size and may include abuse of other agents, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

    Dependence

    Behaviors Associated with Addiction

    Continued abuse of testosterone and other anabolic steroids, leading to

    addiction is characterized by the following behaviors:


    Taking greater dosages than prescribed


    Continued drug use despite medical and social problems due to drug use

    Spending significant time to obtain the drug when supplies of the drug are interrupted


    Giving a higher priority to drug use than other obligations

    Having difficulty in discontinuing the drug despite desires and attempts to do so


    Experiencing withdrawal symptoms upon abrupt discontinuation of use


    Physical dependence is characterized by withdrawal symptoms after abrupt drug discontinuation or a significant dose reduction of a drug. Individuals taking supratherapeutic doses of testosterone may experience withdrawal symptoms lasting for weeks or months which include depressed mood, major depression, fatigue, craving, restlessness, irritability, anorexia, insomnia, decreased libido and hypogonadotropic hypogonadism.


    Drug dependence in individuals using approved doses of testosterone for approved indications has not been documented.

    Overdosage


    There have been no reports of acute overdosage with the androgens.


    Testosterone Cypionate Dosage and Administration


    Prior to initiating Testosterone Cypionate Injection, confirm the diagnosis of hypogonadism by ensuring that serum testosterone concentrations have been measured in the morning on at least two separate days and that these serum testosterone concentrations are below the normal range.


    Testosterone Cypionate Injection is for intramuscular use only.


    It should not be given intravenously. Intramuscular injections should be given deep in the gluteal muscle.


    The suggested dosage for Testosterone Cypionate Injection varies depending on the age, sex, and diagnosis of the individual patient. Dosage is adjusted according to the patient's response and the appearance of adverse reactions.

    Various dosage regimens have been used to induce pubertal changes in hypogonadal males; some experts have advocated lower dosages initially, gradually increasing the dose as puberty progresses, with or without a decrease to maintenance levels. Other experts emphasize that higher dosages are needed to induce pubertal changes and lower dosages can be used for maintenance after puberty. The chronological and skeletal ages must be taken into consideration, both in determining the initial dose and in adjusting the dose.


    For replacement in the hypogonadal male, 50–400 mg should be administered every two to four weeks.


    Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Warming and shaking the vial should redissolve any crystals that may have formed during storage at temperatures lower than recommended.



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