S4 /Andarine/ Acetamidoxolutamide 401900-40-1 Cutting Excess Body
Fat and Bulking
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S4 (Andarine) or Acetamidoxolutamide, is a SARM (Selective Androgen
Receptor Modulator). S4 is said to be the most potent SARM which
helps sustain lean muscle mass while stimulating fat elimination at
the same time. Today, we’ll take a closer look on everything there
is to know about S4.
What is S4?
To start, let’s describe what a SARM does. There are three type of
chemicals that act on the androgen receptor (AR). One is the an AR
antagonist, which is a chemical that binds to the receptor to
prevent it from activating. The second is an AR agonist, which
binds to the receptor and detaches, then binds again, over and
over. An example of an AR agonist is testosterone, each time the AR
is bonded with testosterone, a signal is sent out to activate a
particular set of genes. The more testosterone that is in the
system, the more AR binding will occur. The third is an AR
modulator, or basically a molecule that attaches to an AR and
changes its structure to react however it wants.
How S4 Works
A SARM such as S-4 is a good example. S-4 attaches to the AR and
sticks to it; each time the AR interacts with testosterone, S-4
forces it to produce genes that exclusively benefit muscle and bone
growth. In other words, S4 is a form of SARM that attaches to the
androgen receptor (AR) the same with regular androgens, the only
variation is that S4 generates selective anabolic activity.
S4 is a SARM with utmost androgenic effects as it around 33% of the
strength of testosterone when attaching to AR. S-4 also increases
the amount of muscle mass produced by desensitizing the AR to the
individual’s natural testosterone to influence a stronger effect.
S-4 is by far the most versatile SARM ever created. Not only is it
the first SARM approved for a stage 2 research study, it has become
the most analyzed and investigated SARM so far. After the discovery
of its anabolic potential, the primary purpose of S-4 aimed to
develop an alternative treatment to age-related muscle wasting,
osteoporosis, and similar symptoms of hypogonadism, or end-stage renal disease.
Aside from preserving lean body mass, S4 can also help improve it.
From a stage 1 study, S-4 has provided evidence of a 3.3 lbs
increase in less than 90 days with no increases exercise or change
in daily diet. An unintended side effect (or benefit if you will)
is the decrease in body fat.
- S-4 should be taken at 50mg-75mg, 5 days out of the week, for 12-16
weeks. As mentioned before, S-4 does not need to be taken on 3
separate occasions throughout the day; but for individuals that
prefer this method, a 25mg dose (roughly half a milliliter) is
recommended once with each of your three main meals.
- Once again, as mentioned above, S-4 does have point of diminishing
returns. This means usage of S-4 passed 75mg or usage of S-4 for
more than 16 weeks will not result in any added muscle mass. There
will not be an increase in side effects either, but you will be
running the risk of AR desensitization and inevitably wasting your
- Dosing with S-4 for less than 6-8 weeks is not recommended and will
not allow the researcher to witness the full benefits of the
Recommended dose for cutting is 50 mg for 6-8 weeks. You should use
it every day then take 2 days off for the duration. Taking S4 daily
for the length of the cycle can lead to changes in eyesight.
Uses of Andarine
- For Cutting (best use of S4)
Andarine’s properties are very alike with steroids Anavar and
Winstrol, the only difference is that S4 can better provide lean
muscle gains. In fact, there have been many cases of bodybuilders
gaining up to 3 pounds of lean muscle while on a caloric deficit!
S4 displays the same binding resemblance to AR, hence presenting
similar fat burning effects.
It also improves vascularity for that “aesthetic” chiseled look
with minimal to no water retention. Unlike steroids, it won’t
affect your joints but reinforce muscle mass and power instead. You
can also say goodbye to painful pumps.
Recommended Dosage: 50 mg for 6-8 weeks.
*Take 2 days off when taking S4 (repeat the cycle after the 2 day
break) to avoid vision side effects.
Use S4 with a more anabolic SARM such as Ostarine for better recomp
results as you’re aiming to gain muscle while losing fat.
Recommended intake is 50-75 mg for 4 to 8 weeks.
S-4 isn’t the sarm that comes to mind when we think “BULKING”, but
it’s properties in muscle gain shouldn’t be overlooked. During the
holiday season, many people take advantage of the excess food and
snacks available and jump on some well known bulking SARMs such as LGD 4033 or RAD 140.