What is clomiphene?
Clomiphene is a non-steroidal fertility medicine. It causes the
pituitary gland to release hormones needed to stimulate ovulation
(the release of an egg from the ovary).
Clomiphene is used to cause ovulation in women with certain medical
conditions (such as polycystic ovary syndrome) that prevent
naturally occurring ovulation.
Clomiphene may also be used for purposes not listed in this
Do not use clomiphene if you are already pregnant.
You should not use clomiphene if you have: liver disease, abnormal
vaginal bleeding, an uncontrolled adrenal gland or thyroid
disorder, an ovarian cyst (unrelated to polycystic ovary syndrome),
or if you are pregnant.
Before taking this medicine
You should not use clomiphene if you are allergic to it, or if you
- abnormal vaginal bleeding;
- an ovarian cyst that is not related to polycystic ovary syndrome;
- past or present liver disease;
- a tumor of your pituitary gland;
- an untreated or uncontrolled problem with your thyroid or adrenal
gland; or if you are pregnant.
To make sure clomiphene is safe for you, tell your doctor if you
have:endometriosis or uterine fibroids.
Do not use clomiphene if you are already pregnant. Talk to your
doctor if you have concerns about the possible effects of this
medicine on a new pregnancy.
Clomiphene can pass into breast milk and may harm a nursing baby.
This medication may slow breast milk production in some women. Tell
your doctor if you are breast-feeding a baby.
Using clomiphene for longer than 3 treatment cycles may increase
your risk of developing an ovarian tumor. Ask your doctor about
your specific risk.
Fertility treatment may increase your chance of having multiple
births (twins, triplets). These are high-risk pregnancies both for
the mother and the babies. Talk to your doctor if you have concerns
about this risk.
How should I take clomiphene?
Use clomiphene exactly as directed by your doctor. Follow all
directions on your prescription label. Your doctor may occasionally
change your dose to make sure you get the best results. Do not take
this medicine in larger or smaller amounts or for longer than
Your doctor will perform medical tests to make sure you do not have
conditions that would prevent you from safely using clomiphene.
Clomiphene is usually taken for 5 days, starting on the 5th day of
your menstrual period. Follow your doctor's instructions.
You will need to have a pelvic examination before each treatment
cycle. You must remain under the care of a doctor while you are
using this medicine.
You will most likely ovulate within 5 to 10 days after you take
clomiphene. To improve your chance of becoming pregnant, you should
have sexual intercourse while you are ovulating.
Your doctor may have you take your temperature each morning and
record your daily readings on a chart. This will help you determine
when you can expect ovulation to occur.
In most cases, clomiphene should not be used for more than 3
If ovulation occurs but you do not get pregnant after 3 treatment
cycles, your doctor may stop treatment and evaluate your
Store at room temperature away from moisture, heat, and light.