Copper Peptide (GHK-Cu)
Copper Peptide (GHK-Cu)
Dry Cool Place
GHK (GHK-Cu) 200mg Copper Peptide (Twist Off Cap)
GHK-Cu, Copper Peptide, is a naturally occurring human tri-peptide.
In plasma, the level of GHK-Cu is about 200 ng/ml at age 20. By the
age of 60, the level drops to 80 ng/ml. Scientific studies
conducted in different research laboratories around the world have
established that human tri-peptide GHK-Cu possesses a plethora of
biological actions including activation of wound healing,
attraction of immune cells, antioxidant and anti-inflammatory
effects, stimulation of collagen and glycosaminoglycan synthesis in
skin fibroblasts and promotion of blood vessels growth. Recent
studies indicate its important role in stem cell biology and
anti-tumor defense. Since GHK-Cu plays an important role in skin
biology, it is widely used in cosmetics as a reparative and
anti-aging ingredient. The levels of GHK decrease as you age.
Reference: ^ Pickart L. The human tri-peptide GHK and tissue
remodeling". J. Biomater. Sci. Polymer Edn. 2008; 19(8):969-988
Peptide Sequence: Gly-His-Lys(Cu2+)
GHK-Cu Human Trials
A 2% GHK gel showed promising results in treatment of 120 diabetic
patients, increasing the percentage of ulcer closure from 60.8% to
98.5%, and decreasing the percentage of infection from 34% to 7%.
Reference: ^ Mulder DPM1, Gerit D.; Patt PhD2, Leonard M.; Sanders
DPM, Lee; et al (1994). "Enhanced healing of ulcers in patients
with diabetes by topical treatment of glycyl-l-histidyl-l-lysine".
Wound Repair Regen 2 (4): 259â€"269.
FACIAL STUDIES: Copper peptide GHK-Cu is widely used in anti-aging
cosmetics (INCI name: Copper tripeptide-1).Several controlled
facial studies confirmed anti-aging, firming and anti-wrinkle
activity of copper peptide GHK-Cu. Abdulghani et al. established
that facial cream containing GHK-Cu increased collagen in photoaged
skin of 20 female volunteers, performing better than vitamin C and
retinoic acid. Leyden et al. conducted 12 weeks facial study of
GHK-Cu containing face and eye cream, reporting significant
improvement of skin laxity, clarity and appearance, reduced fine
lines and the depths of wrinkles and increased skin density and
thickness comparing to placebo. GHK-Cu eye cream performed better
than vitamin K cream. Finkley et al. conducted 12 week facial study
on 67 women and reported that GHK-Cu cream applied twice daily
improved aged skin appearance, increased thickness, reduced
wrinkles and strongly stimulated dermal keratinocyte proliferation
as determined by histological analysis of biopsies. The same study
found copper peptide GHK-Cu to be non-toxic and non-irritating.
HAIR GROWTH BENEFITS:
Copper peptide GHK-Cu and its analogues were found to strongly
stimulate hair growth. The efficiency of synthetic analog of GHK-Cu
was similar to that of 5% minoxidil.
Refernces: ^ Abdulghani, AA, Sherr S, Shirin S, Solodkina G, Tapia
EM,Gottlieb AB. Effects of topical creams containing vitamin C, a
copper-binding peptide cream and melatonin compared with tretinoin
on the ultrastructure of normal skin - A pilot clinical,
histologic, and ultrastructural study. Disease Manag Clin Outcomes.
1998;1:136-141 ^ Leyden J, Stephens T, Finkey MB, Appa, Y, Barkovic
S, Skin Care Benefits of Copper Peptide Containing Facial Cream.
Amer Academy Dermat Meeting, February 2002, Abstract P68, P69 ^
Finkley MB, Appa Y, Bhandarkar S. Copper Peptide and Skin.
Cosmeceuticals and Active Cosmetic, 2nd Edition, P. Eisner and H.I.
Maibach (Eds.) Marcel Dekker.
HUMAN FIBROBLASTS: Recent studies have revealed many new aspects of
molecular actions of the copper-peptide GHK-Cu. Pollard at al
established that GHK-Cu is able to restore function of human
fibroblasts damaged by radiation treatment thus accelerate the
healing and regenerative processes.
NERVE REGENERATION: In 2005, Ahmed et al. demonstrated that GHK
promotes nerve regeneration. Axon regeneration was studied using
collagen tubes with incorporated peptides. GHK increased the
production of nerve growth factors, expression of integrins and
increased the rate of regeneration of myelinated nerve fibers.